Article

Zevaskyn (prademagene zamikeracel) for wound treatment in individuals with recessive dystrophic epidermolysis bullosa: A therapeutics bulletin of the American College of Medical Genetics and Genomics (ACMG)

2026-08-01

Abstract excerpt

Collagen Type VII, Alpha-1 is encoded by the COL7A1 gene (HGNC:2214) on chromosome 3p21.31. Biallelic pathogenic variants in COL7A1 are associated with autosomal recessive dystrophic epidermolysis bullosa (RDEB), resulting from a defect of COL7A1 function in anchoring fibrils at the cell-cell or cell-matrix junctions.1 RDEB is characterized by chronic blistering and impaired wound healing starting as early as the...

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Literature Corpus work: 14c7131f-c12c-533d-afc0-747b8897c10d
DOI: 10.1016/j.gimo.2026.104408

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