Article

Expression and T cell Regulatory Action of the PD-1 Immune Checkpoint in the Ovary and Fallopian Tube

2020-06-07

Abstract excerpt

The P rogrammed Cell D eath Protein-1 (PD-1/PDCD-1/CD279) checkpoint has powerful immunomodulatory action, including in the context of cancer. PD-1 receptor activation by its ligands (PD-L1/2) is associated with downregulated immune response, and tumor cells can avoid surveillance via PD-1 and/or ligand expression. While receptor expression is largely limited to lymphoid, myeloid, and tumor cells, we show that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1476ec20-014c-5eb9-b0b1-34e4d904b666
DOI: 10.1101/2020.06.06.138123

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expression and T cell Regulatory Action of the PD-1 Immune Checkpoint in the Ovary and Fallopian TubeDOI 10.1101/2020.06.06.138123Read

NEAT1 in Ovarian Cancer: A Key Regulator of Tumor Progression, Follicular Fluid Dynamics, and Therapeutic ResistanceSemantic proximity Read

A comprehensive cell profiling reveals new cell subtypes and immune dysfunction in peritoneal fluid of endometriosisSemantic proximity Read

Small and large extracellular vesicles from human preovulatory follicular fluid display distinct ncRNA cargo profile and differential effect on granulosa cell line KGNSemantic proximity Read

Bioengineered extracellular vesicles presenting PD-L1 and Gal-9 to ameliorate new-onset primary ovarian insufficiency (POI)Semantic proximity Read

Expression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunctionSemantic proximity Read

Ligands, receptors and transcription factors that mediate inter-cellular and intra-cellular communication during ovarian follicle developmentSemantic proximity Read

Predicting developmental relationships of tumor resident and circulating T cells in ovarian cancerSemantic proximity Read

Immune and oxidative stress disorder in ovulation-dysfunction women revealed by single-cell transcriptomeSemantic proximity Read

Decoding Functional and Developmental Trajectories of Tissue-Resident Uterine Dendritic Cells Through Integrative OmicsSemantic proximity Read

Dysgerminoma germ cell tumors exhibit high expression of PD-L1 and are associated with high levels of tumor-infiltrating lymphocytes and a good patient prognosisSemantic proximity Read

PD-1 is expressed by and regulates human group 3 innate lymphoid cells in human deciduaSemantic proximity Read

Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancerSemantic proximity Read