Article

Applying Metabolomics and Aptamer-based Proteomics to Determine Pathophysiologic Differences in Decompensated Cirrhosis Patients Hospitalized with Acute Kidney Injury

2024-05-09

Abstract excerpt

<title>Abstract</title> <p>Methods A case-control study of 97 patients hospitalized at our institution. We performed aptamer-based proteomics and metabolomics on serum biospecimens obtained within 72 hours of admission. We compared the proteome and metabolome by the AKI phenotype (i.e., HRS-AKI, ATN) and by AKI recovery (decrease in sCr within 0.3 mg/dL of baseline) using ANCOVA analyses adjusting for demographi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 138e9547-a1ec-5561-886f-d942075060ab
DOI: 10.21203/rs.3.rs-4344179/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Applying Metabolomics and Aptamer-based Proteomics to Determine Pathophysiologic Differences in Decompensated Cirrhosis Patients Hospitalized with Acute Kidney InjuryDOI 10.21203/rs.3.rs-4344179/v1Read

Quantitative Plasma Proteomics Identifies Metallothioneins as a Marker of Acute-on-Chronic Liver Failure Associated Acute Kidney InjurySemantic proximity Read

Early Identification of At-Risk Patients: Proteomic Signature Predicts Progression to Decompensated CirrhosisSemantic proximity Read

Personalized acute kidney injury treatment.Semantic proximity Read

Diagnosis and Staging of Metabolic Dysfunction-Associated Steatotic Liver Disease Using Biomarker-Directed Aptamer PanelsSemantic proximity Read

Phenotyping of Acute Kidney Injury: Beyond Serum Creatinine.Semantic proximity Read

Urinary neutrophil gelatinase-associated lipocalin predicts mortality and identifies acute kidney injury in cirrhosis.Semantic proximity Read

Urinary proteomics identifies distinct immunological profiles of sepsis associated AKI sub-phenotypes.Semantic proximity Read

Identification of Subclasses of Decompensated Cirrhotic Patients with Acute Kidney Injury with Different Responses to Fluid Input.Semantic proximity Read

Uremic Toxins and Inflammation: Metabolic Pathways Affected in Stage 5 Kidney DiseaseSemantic proximity Read

Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity.Semantic proximity Read

Plasma multi-omics outlines association of urobilinogen with corticosteroid non-response, inflammation and leaky gut in Sever Alcoholic HepatitisSemantic proximity Read

A plasma peptidomic signature reveals extracellular matrix remodeling and predicts prognosis in alcohol-related hepatitisSemantic proximity Read