Article

Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids

2021-04-05

Abstract excerpt

Non-invasive acquisition of mRNA data from the skin would be extremely useful for understanding skin physiology and diseases. Inspired by the holocrine process, in which the sebaceous glands secrete cell contents into the sebum, we focused on the possible presence of mRNAs in skin surface lipids (SSLs). We found that measurable human mRNAs exist in SSLs, where sebum protects them from degradation by RNases. The Am...

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Literature Corpus work: 12f715c7-db64-544c-a8b8-4b54496ccc79
DOI: 10.1101/2021.04.04.438351

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