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Non-invasive human skin transcriptome analysis using mRNA in skin surface lipids

9 Mar 2022

Abstract excerpt

Non-invasive acquisition of mRNA data from the skin can be extremely useful for understanding skin physiology and diseases. Inspired by the holocrine process, in which the sebaceous glands secrete cell contents into the sebum, we focused on the possible presence of mRNAs in skin surface lipids (SSLs). We found that measurable levels of human mRNAs exist in SSLs, where the sebum protects them from degradation by...

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PMID: 35264722
DOI: 10.1038/s42003-022-03154-w

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