Article

A BRCT Domain-Containing Protein Induced in Early Phagocytosis Plays a Crucial Role in Mucorales Pathogenesis

2025-05-16

Abstract excerpt

<h4>ABSTRACT</h4> Mucormycosis, caused by Mucoralean fungi, is among the most lethal fungal diseases, and a deeper understanding of its pathogenesis is urgently needed. Transcriptomic profiling of virulent (WT) and an RNAi-deficient strain ( r3b2 Δ) of M. lusitanicus strains during phagocytosis uncovered thousands of differentially expressed genes (DEGs), highlighting early metabolic activation as a key surviva...

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Literature Corpus work: 12f24905-1c9a-5b24-bc20-120422d1cad1
DOI: 10.1101/2025.05.13.652844

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