Article

“Amantadine disrupts lysosomal gene expression; potential therapy for COVID19”

2020-04-05

Abstract excerpt

SARS-coronavirus 2 is the causal agent of the COVID-19 outbreak. SARS-Cov-2 entry into a cell is dependent upon binding of the viral spike (S) protein to cellular receptor and on cleavage of the spike protein by the host cell proteases such as Cathepsin L and Cathepsin B. CTSL/B are crucial elements of lysosomal pathway and both enzymes are almost exclusively located in the lysosomes.CTSL disruption offers potenti...

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Literature Corpus work: 1140cd7c-6fcb-55d1-a542-154856255d5c
DOI: 10.1101/2020.04.05.026187

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