Article

Correlation Analysis of 21-Gene Recurrence Score with Gene Pathway Expression and Clinicopathological Features in Hormone Receptor-Positive Early-Stage Breast Cancer

2026-08-25

Abstract excerpt

<title>Abstract</title> <p>Background The 21-gene recurrence score (RS) is widely used to guide adjuvant chemotherapy decisions in hormone receptor (HR)-positive, HER2-negative early breast cancer. However, the independent contributions of individual gene pathway scores to RS have not been simultaneously modeled in a multivariate framework, particularly in real-world Asian populations. This study aimed to invest...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10ad9596-d1a0-5d2f-bb68-794e9cb92045
DOI: 10.21203/rs.3.rs-10549349/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Correlation Analysis of 21-Gene Recurrence Score with Gene Pathway Expression and Clinicopathological Features in Hormone Receptor-Positive Early-Stage Breast CancerDOI 10.21203/rs.3.rs-10549349/v1Read

Impact of Different Modules of 21-Gene Assay in Early Breast Cancer PatientsSemantic proximity Read

Comparative Evaluation of a 28-Gene versus 70-Gene Panel for Recurrence Risk Prediction in Early-Stage HR-Positive/HER2-Negative Breast Cancer in Chinese WomenSemantic proximity Read

The Clinical Impact of 21-Gene Recurrence Score on Treatment Decisions for Patients with Hormone Receptor-Positive Early Breast Cancer in KoreaSemantic proximity Read

Development and clinical utility of a 21-gene recurrence score prognostic assay in patients with early breast cancer treated with tamoxifen.Semantic proximity Read

Prospective Validation of a 21-Gene Expression Assay in Breast CancerSemantic proximity Read

A nomogram to predict the high-risk RS in HR+/HER2-breast cancer patients older than 50 years of ageSemantic proximity Read

Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast CancerSemantic proximity Read

21-Gene recurrence score decreases receipt of chemotherapy in ER+ early-stage breast cancer: an analysis of the NCDB 2010-2013.Semantic proximity Read

Deep learning from HE slides to predict the clinical benefit from adjuvant chemotherapy in hormone receptor-positive breast cancerSemantic proximity Read

Utilization and impact of 21-gene recurrence score assay for breast cancer in clinical practice across the United States: lessons learned from the 2010 to 2012 National Cancer Data Base analysis.Semantic proximity Read

RecurrenceOnline: an online analysis tool to determine breast cancer recurrence and hormone receptor status using microarray data.Semantic proximity Read

A 95-gene Signature Stratifies Recurrence Risk of Invasive Disease in ER-positive, HER2-negative, Node-negative Breast Cancer With Intermediate 21-gene Signature Recurrence ScoresSemantic proximity Read