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Article

Prospective Validation of a 21-Gene Expression Assay in Breast Cancer

28 Sept 2015

Abstract excerpt

BACKGROUND: Prior studies with the use of a prospective-retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, a prospectively conducted study in a uniformly treated population provides the highest level of evidence supporting the clinical validity and usefulness of a biomarker. METHODS: We performed a prospective...

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PMID: 26412349
DOI: 10.1056/nejmoa1510764

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