Back to search

Article

Food-grade titanium dioxide translocates across the oral mucosa in pigs and induces genotoxicity in an in vitro model of human oral epithelium

2022-07-05

Abstract excerpt

<h4>Background: </h4> Food-grade titanium dioxide (TiO 2 ), composed of nano- and submicron-sized particles, is used worldwide in various foodstuffs, toothpastes and pharmaceutical tablets as a whitening and opacifying agent. Its use as a food additive (E171 in EU) has raised concerns for human health regarding its systemic availability, tissue accumulation, genotoxicity and promotion of precancerous lesions. Howe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0f9ec961-8f31-5261-b326-51ba0f03a21c
DOI
10.21203/rs.3.rs-1788223/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Food-grade titanium dioxide translocates across the oral mucosa in pigs and induces genotoxicity in an in vitro model of human oral epitheliumDOI 10.21203/rs.3.rs-1788223/v1
Toxicity of orally administered food-grade titanium dioxide nanoparticlesSemantic proximity
Jejunal villus absorption and paracellular tight junction permeability are major routes for early intestinal uptake of food-grade TiO2 particles: an in vivo and ex vivo study in miceSemantic proximity
Validating Enteroid-Derived Monolayers From Murine Gut Organoids for Toxicological Testing of Inorganic Particles: Proof-of-Concept With Food Grade Titanium DioxideSemantic proximity
Genome-wide DNA methylation sequencing reveals the involvement of ferroptosis in hepatotoxicity induced by dietary exposure to food-grade titanium dioxideSemantic proximity
Cell-Type specific toxicity of heptadecafluorooctanesulfonic acid (PFOS), pentadecafluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA): mechanistic insights into oral exposure pathwaysSemantic proximity
A pro-oxidant combination of resveratrol and copper down-regulates hallmarks of cancer and immune checkpoints in patients with advanced oral cancer: Results of an exploratory study (RESCU 004)Semantic proximity
Cytotoxicity and Genotoxicity of E-Cigarette Generated Aerosols Containing Diverse Flavoring Products and Nicotine in Oral Epithelial Cell LinesSemantic proximity
UVB-aged microplastics and cellular damage : An in vitro studySemantic proximity
Towards the Standardization of Intestinal In Vitro Advanced Barrier Model for Nanoparticles Uptake and Crossing: The SiO2 Case StudySemantic proximity
Chronic exposure to nanosized, anatase titanium dioxide is not cyto- or genotoxic to Chinese hamster ovary cells.Semantic proximity
Evaluation of cytotoxic, genotoxic and inflammatory responses of nanoparticles from photocopiers in three human cell linesSemantic proximity
Genotoxic and mutagenic properties of Ni and NiO nanoparticles investigated by comet assay, γ-H2AX staining, Hprt mutation assay and ToxTracker reporter cell lines.Semantic proximity
Select a neighboring publication to make it the new centre.