Article

Temperature-driven isoform switching reprograms developmental gene expression in a human fungal pathogen

2026-08-27

Abstract excerpt

Post-transcriptional regulation is key to development, and yet little is known about how RNA isoform choice contributes to developmental choices in fungi. Here we assemble the first isoform-level transcriptome of Histoplasma , a ubiquitous human fungal pathogen that grows as an infectious environmental form (hyphae) or a pathogenic host form (yeast) in response to temperature. We find extensive morphology-associa...

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Literature Corpus work: 0f57d105-fbba-52b9-a4c0-570aef4708e5
DOI: 10.64898/2026.08.26.747414

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