Article

A translational swine model for Crohn’s disease

2022-07-10

Abstract excerpt

Crohn’s Disease (CD) is incurable, and represents a lifelong burden for patients and its incidence is increasing worldwide. A key contributing factor is a dysregulated immune response. Here we report the generation of genome edited pigs with a deletion of the transcript-destabilizing AU-rich element (ARE) and a constitutive decay element (CDE) in the TNF gene which recapitulate major characteristics of human CD,...

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Literature Corpus work: 0e67e7a4-f461-56d1-ba2c-f2f1546f0e4e
DOI: 10.1101/2022.07.08.499360

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