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Ocular Safety and Efficacy of AAV-mediated Tyrosinase Gene Augmentation in a Nonhuman Primate Model

2026-07-14

Abstract excerpt

<h4>Purpose</h4> Oculocutaneous albinism type 1 (OCA1) is an inherited disorder caused by tyrosinase ( TYR ) gene mutations. Affected individuals experience visual impairment and severe photosensitivity from ocular hypomelanosis, with no current treatments. We evaluated the safety and efficacy of a TYR -encoding adeno-associated virus (AAV) vector in healthy rhesus macaques as a potential OCA1 treatment. <h4>M...

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Literature Corpus work
0e28fa47-8ce7-5f1b-a639-b4e12eb32932
DOI
10.64898/2026.07.13.738268
Open publication

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