Article

Molecular Mechanisms of Photoaging in Human Skin <i>In Vivo</i> and Their Prevention by All‐Trans Retinoic Acid

1999-02-01

Abstract excerpt

Abstract— Solar UV radiation damages human skin, affecting skin tone and resiliency and leading to premature aging (photoaging), the symptoms of which include leathery texture, wrinkles, mottled pigmentation, laxity and sallowness. We propose that photoaging results largely from UV induction of matrix metalloproteinases (MMP) that degrade skin collagen. We find that pretreatment of human skin with all‐ trans retin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0e24b2fe-2e80-57b2-8132-bd0f13f23ced
DOI: 10.1111/j.1751-1097.1999.tb03268.x

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular Mechanisms of Photoaging in Human Skin <i>In Vivo</i> and Their Prevention by All‐Trans Retinoic AcidDOI 10.1111/j.1751-1097.1999.tb03268.xRead

Molecular Mechanisms of Photoaging in Human Skin In Vivo and Their Prevention by All-Trans Retinoic AcidSemantic proximity Read

Molecular Mechanisms of Photoaging and its Prevention by Retinoic Acid: Ultraviolet Irradiation Induces MAP Kinase Signal Transduction Cascades that Induce Ap-1-Regulated Matrix Metalloproteinases that Degrade Human Skin In VivoSemantic proximity Read

Photoaging of the skin from phenotype to mechanisms.Semantic proximity Read

Photoaging Decoded: Extracellular Matrix Alterations and Mechanisms via Mitogen-Activated Protein Kinase/Matrix Metalloproteinase, Transforming Growth Factor-β Pathways, and Glycosaminoglycan MetabolismSemantic proximity Read

Photoaging of human skinSemantic proximity Read

New insights in photoaging, UVA induced damage and skin typesSemantic proximity Read

Photoprotection beyond Ultraviolet Radiation – Effective Sun Protection Has to Include Protection against Infrared A Radiation-Induced Skin DamageSemantic proximity Read

Human Skin Aging and the Anti-Aging Properties of RetinolSemantic proximity Read

Low to Moderate Doses of Infrared A Irradiation Impair Extracellular Matrix Homeostasis of the Skin and Contribute to Skin PhotodamageSemantic proximity Read

Infrared and skin: Friend or foeSemantic proximity Read

Upregulation of MMP12 and Its Activity by UVA1 in Human Skin: Potential Implications for PhotoagingSemantic proximity Read

Infrared Radiation-Induced Matrix Metalloproteinase in Human Skin: Implications for ProtectionSemantic proximity Read