Article

Characterization of the frameshift c.515dupC knock-in mouse model of HSPB8-associated myopathy (MFM13) and evaluation of Trehalose as autophagy-modulating therapy

2026-08-09

Abstract excerpt

Heat shock protein family B member 8 (HSPB8) is a chaperone involved in the chaperone-assisted selective autophagy (CASA) complex. HSPB8 in conjunction with cochaperone BAG3, promotes autophagy-mediated removal of misfolded proteins associated with various neurodegenerative diseases. Mutations in HSPB8 , previously associated with Charcot Marie Tooth disease type 2L, have recently been linked to an autosomal domi...

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Literature Corpus work: 0d3a1550-7c7c-5705-b17b-35c17dbf5e21
DOI: 10.64898/2026.08.04.742148

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