Examining the Variability in Adrenal Cortical Suppression Among Patients Receiving Etomidate for General Anesthesia in Morning vs. Evening Sessions: A Randomized Clinical Trial

Abstract excerpt

<title>Abstract</title> <p> Etomidate provides significant clinical benefits; however, its potential to suppress adrenal cortical function raises concerns. Adrenocorticosteroid secretion follows a distinct circadian rhythm, peaking in the morning and declining significantly in the evening. Nevertheless, the impact of these fluctuations on etomidate-induced adrenal suppression and postoperative outcomes remains u...

Topics

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• Adrenal Cortex Hormones
• Animals, Genetically Modified
• Hemodynamics
• Hypnotics and Sedatives
• Mutation
• Receptors, Adrenergic
• Receptors, GABA-A
• Steroids

Identifiers and source

Literature Corpus work

0cd6d507-5cf3-523b-9f1b-68e480580d0c

DOI

10.21203/rs.3.rs-7463117/v1