Article

Three-dimensional H&E histopathology powered by deep learning-assisted multimodal nonlinear microscopy

2025-10-28

Abstract excerpt

<title>Abstract</title> <p>The diagnostic and prognostic potential of histopathology can be significantly enhanced with three-dimensional (3D) imaging. Histopathology relies on the gold-standard 2D inspection of hematoxylin and eosin (H&E)-stained tissue sections with a brightfield microscope. We introduce a novel methodology termed nonlinear-H&E (N-H&E) that utilizes inherent optical sectioning of nonlinear micr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0c9216c5-ea70-5669-b3e3-b5413a836821
DOI: 10.21203/rs.3.rs-7402116/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Three-dimensional H&E histopathology powered by deep learning-assisted multimodal nonlinear microscopyDOI 10.21203/rs.3.rs-7402116/v1Read

VS-FPM: large-format, label-free virtual histopathology microscopySemantic proximity Read

Cycle-consistent Generative Adversarial Network for computational hematoxylin-and-eosin staining of fluorescence confocal microscopic images of basal cell carcinoma tissueSemantic proximity Read

Virtual Histological Staining of Label-Free Total Absorption Photoacoustic Remote Sensing (TA-PARS)Semantic proximity Read

Label-free imaging of collagen fibers in tissue slices using phase imaging with computational specificitySemantic proximity Read

Large-scale segmentation model facilitates intraoperative histopathology by third harmonic generation microscopySemantic proximity Read

Machine learning-enabled cancer diagnostics with widefield polarimetric second-harmonic generation microscopySemantic proximity Read

Quantification of collagen and associated features from H&E-stained whole slide pathology images across cancer types using a physics-based deep learning modelSemantic proximity Read

Automated whole-organ histological imaging assisted with ultraviolet-excited sectioning tomography and deep learningSemantic proximity Read

Prostate cancer histopathology with label-free multispectral deep UV microscopy quantifies phenotypes of tumor grade and aggressivenessSemantic proximity Read

Synthesis of diagnostic quality cancer pathology imagesSemantic proximity Read

OCT2Hist: Non-Invasive Virtual Biopsy Using Optical Coherence TomographySemantic proximity Read

Prostate cancer histopathology using label-free multispectral deep-UV microscopy quantifies phenotypes of tumor aggressiveness and enables multiple diagnostic virtual stains.Semantic proximity Read