Article

Vigabatrin for SCN2A R853Q Variant-Associated Infantile Epilepsy Spasms Syndrome: Limited Efficacy and Increased Risk of Vigabatrin-Associated Brain Abnormalities on MRI

2026-08-28

Abstract excerpt

<title>Abstract</title> Background Infantile epilepsy spasms syndrome (IESS) caused by the <italic>SCN2A</italic> R853Q loss-of-function (LOF) mutation is refractory or resistant. Vigabatrin (VGB) is a common treatment for IESS, but it carries a risk of Vigabatrin-Associated Brain Abnormalities on MRI (VABAM). This study investigates the efficacy and safety of VGB in infants with IESS caused by the <ital...

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Literature Corpus work: 0c709dad-132c-55ae-91a2-4cd832677cf4
DOI: 10.21203/rs.3.rs-10599141/v1

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