Article
TonB-dependent uptake of β-lactam antibiotics in the opportunistic human pathogen Stenotrophomonas maltophilia.
Molecular microbiology - 1 Feb 2020
Calvopiña Karina, Dulyayangkul Punyawee, Heesom Kate J, Avison Matthew B
Abstract excerpt
The β-lactam antibiotic ceftazidime is one of the handful of drugs with proven clinical efficacy against the important opportunistic human pathogen Stenotrophomonas maltophilia. Here, we show that mutations in the energy transducer TonB, encoded by smlt0009 in S. maltophilia, confer ceftazidime resistance and smlt0009 mutants have reduced uptake of ceftazidime. This breaks the dogma that β-lactams enter...
Topics
- Anti-Infective Agents
- Bacterial Proteins
- Ceftazidime
- Drug Resistance, Bacterial
- Drug Resistance, Multiple, Bacterial
- Humans
- Membrane Proteins
- Microbial Sensitivity Tests
- Mutation
- Peptides, Cyclic