Article
Noninvasive fetal genotyping of single nucleotide variants and linkage analysis for prenatal diagnosis of monogenic disorders.
Human genomics - 27 Jul 2022
Wu Wenman, Zhou Xuanyou, Jiang Zhengwen, Zhang Dazhi, Yu Feng, Zhang Lanlan, Wang Xuefeng, Chen Songchang, Xu Chenming
Abstract excerpt
BACKGROUND: High-cost, time-consuming and complex processes of several current approaches limit the use of noninvasive prenatal diagnosis (NIPD) for monogenic disorders in clinical application. Thus, a more cost-effective and easily implementable approach is required. METHODS: We established a low-cost and convenient test to noninvasively deduce fetal genotypes of the mutation and single nucleotide polymorphisms...
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