Article

Impact of Updated NCCN Guidelines on Clinical Management and Risk Communication for CHEK2 p.I157T Carriers in Breast Cancer

2026-02-22

Abstract excerpt

<title>Abstract</title> <p> In 2023, the National Comprehensive Cancer Network® (NCCN®) updated its guidelines for managing breast cancer risk in patients with a <italic>CHEK2</italic> p.I157T variant, recommending de-escalation of enhanced screening based on this variant alone. This shift reflects evidence that some missense variants carry a lower cancer risk than <italic>CHEK2</italic> loss-of-function var...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b6a366b-5424-5ed7-b6d1-3654718c4723
DOI: 10.21203/rs.3.rs-8833709/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impact of Updated NCCN Guidelines on Clinical Management and Risk Communication for CHEK2 p.I157T Carriers in Breast CancerDOI 10.21203/rs.3.rs-8833709/v1Read

Impact of updated NCCN guidelines on clinical management and risk communication for CHEK2 p.I157T carriers in breast cancer.Semantic proximity Read

Comparing Cancer Risk Management between Females with Truncating CHEK2 1100delC versus Missense CHEK2 I157T Variants.Semantic proximity Read

Management of individuals with germline pathogenic/likely pathogenic variants in CHEK2: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).Semantic proximity Read

EMQN best practice guidelines for genetic testing in hereditary breast and ovarian cancer.Semantic proximity Read

An analysis of the impact of annual cancer genetic testing guideline updates on a past patient population.Semantic proximity Read

Utility of Expedited Hereditary Cancer Testing in the Surgical Management of Patients with a New Breast Cancer Diagnosis.Semantic proximity Read

NSGC Practice Guideline: Risk Assessment and Genetic Counseling for Hereditary Breast and Ovarian CancerSemantic proximity Read

Consensus Guidelines on Genetic` Testing for Hereditary Breast Cancer from the American Society of Breast SurgeonsSemantic proximity Read

Reinterpretation of BRCA1 and BRCA2 variants of uncertain significance in patients with hereditary breast/ovarian cancer using the ACMG/AMP 2015 guidelinesSemantic proximity Read

Update: variable implementation of the 2018 UKCGG/UKGTN guidelines for breast cancer gene panel tests offered by UK genetics services.Semantic proximity Read

NCCN Updates Guidelines for Hereditary Cancer Risks.Semantic proximity Read