Article

HSP90 inhibitor NVP-HSP990 alleviates rotavirus infection

2023-06-16

Abstract excerpt

Rotavirus (RV) infection is a significant cause of hospitalization and mortality in infants and young children. Although conventional symptomatic treatments usually appear effective, tens of thousands of infants and young children still die each year due to the absence of safe and effective anti-RV drugs. Heat shock protein 90 (HSP90) is usually required for efficient viral infection; however, due to unsatisfactor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0802c4da-24b3-5960-8a7c-90e83b39b500
DOI: 10.1101/2023.06.15.545197

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HSP90 inhibitor NVP-HSP990 alleviates rotavirus infectionDOI 10.1101/2023.06.15.545197Read

Human coronavirus dependency on host heat shock protein 90 reveals an antiviral targetSemantic proximity Read

Hsp90 Regulates GCRV-II Proliferation by Interacting with VP35 as Its Receptor and ChaperoneSemantic proximity Read

Molecular Chaperone Hsp90 Is a Therapeutic Target for NorovirusesSemantic proximity Read

Advances in the Development of Antiviral Compounds for Rotavirus Infections.Semantic proximity Read

Heat Shock Protein 90 Positively Regulates Chikungunya Virus Replication by Stabilizing Viral Non-Structural Protein nsP2 during InfectionSemantic proximity Read

Broad action of Hsp90 as a host chaperone required for viral replicationSemantic proximity Read

The Heat Shock Protein 70 Family of Chaperones Regulates All Phases of the Enterovirus A71 Life CycleSemantic proximity Read

Human Rotavirus Diarrhea Is Associated with Altered Trafficking and Expression of Apical Membrane Transport ProteinsSemantic proximity Read

Role of Heat Shock Proteins (HSP70 and HSP90) in Viral InfectionSemantic proximity Read

Phenanthridine Derivative Host Heat Shock Cognate 70 Down-Regulators as Porcine Epidemic Diarrhea Virus InhibitorsSemantic proximity Read

Hsp90 β is critical for the infection of severe fever with thrombocytopenia syndrome virusSemantic proximity Read

Purinergic Signaling Drives Multiple Aspects of Rotavirus PathophysiologySemantic proximity Read