Article

Absence of phosphorylated CDK4, a biomarker of intrinsic resistance to CDK4/6 inhibitors in head and neck squamous cell carcinoma, can be predicted by their gene expression profile

2025-11-11

Abstract excerpt

The level of T172 CDK4 phosphorylation, required for enzyme activity and entry in the normal cell cycle, was variable in two head and neck squamous carcinoma (HNSCC) cohorts, corresponding cell lines and patient-derived tumor xenograft (PDTX) models. Actively proliferating tumors or models lacking CDK4 phosphorylation had defective pRb, elevated E2F1 or CCNE1 expression or were HPV-positive. CDK4 phosphorylation...

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Literature Corpus work: 0755e175-7e8b-5736-bbab-27945dfbced5
DOI: 10.1101/2025.11.10.25339594

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