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A pan-genome approach to decipher variants in the highly complex tandem repeat of <i>LPA</i>

2022-06-09

Abstract excerpt

Lp(a) is an important factor in Coronary Heart disease risk, and its expression is correlated with the length of the LPA gene. The KIV-2 region of LPA consists of variable tandem repeats whose number is highly variable across individuals. Little is known about the inner diversity of the KIV-2 repeats themselves. Here we utilize a pan-genome graph approach across 47 haplotype resolved assemblies to identify unexp...

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Identifiers and source

Literature Corpus work
07179590-f0fa-5f64-a616-80b703b6f6d4
DOI
10.1101/2022.06.08.495395
Open publication

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A pan-genome approach to decipher variants in the highly complex tandem repeat of <i>LPA</i>DOI 10.1101/2022.06.08.495395
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