Article

Mesenchymal Stem Cell Therapy Ameliorates Metabolic Dysfunction and Restores Fertility in a PCOS Mouse Model Through Interleukin-10

2021-04-23

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-age women. Excessive inflammation and elevated androgen production from ovarian theca cells are key features of PCOS. Human bone marrow mesenchymal stem cells (BM-hMSC) and their secreted factors (secretome) exhibit robust anti-inflammatory capabilities in variou...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 06659b12-9b60-5076-9380-e5bf7453f421
DOI: 10.21203/rs.3.rs-444566/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mesenchymal Stem Cell Therapy Ameliorates Metabolic Dysfunction and Restores Fertility in a PCOS Mouse Model Through Interleukin-10DOI 10.21203/rs.3.rs-444566/v1Read

Hypoxia Mesenchymal Stem Cell Secretome Enhances IL-10 via STAT3 Pathway in a Rat PCOS ModelSemantic proximity Read

Mesenchymal Stem Cells as a Bio Organ for Treatment of Female InfertilitySemantic proximity Read

IL-18BP Therapy Ameliorates Reproductive and Metabolic Phenotypes in a PCOS Mouse Model by Relieving Inflammation, Fibrosis and Endoplasmic Reticulum Stress.Semantic proximity Read

Signaling pathways and targeted therapeutic strategies for polycystic ovary syndromeSemantic proximity Read

Application of Mesenchymal Stem Cells in Female Infertility Treatment: Protocols and Preliminary ResultsSemantic proximity Read

Autologous Human Mesenchymal Stem Cell-Based Therapy in Infertility: New Strategies and Future PerspectivesSemantic proximity Read

Research on the self-healing ability of polycystic ovarian syndrome (PCOS) in mice model and its impact on offspringSemantic proximity Read

Mesenchymal Stem Cells in Preclinical Infertility Cytotherapy: A Retrospective ReviewSemantic proximity Read

Multiple treatments with human embryonic stem cell-derived mesenchymal progenitor cells preserved fertility and ovarian function of perimenopausal mice undergoing natural aging.Semantic proximity Read

Mesenchymal stem cells-derived exosomes as a promising new approach for the treatment of infertility caused by polycystic ovary syndromeSemantic proximity Read

Human mesenchymal stem cell treatment of premature ovarian failure: new challenges and opportunitiesSemantic proximity Read

Systems Genetics Cytokine Screen Identifies T cells as Necessary for Letrozole-Induced LH Elevation in a PMOS-like Mouse ModelSemantic proximity Read