Article

Challenges in predicting protein-protein interactions of understudied viruses: Arenavirus-Human interactions

2025-04-21

Abstract excerpt

Understanding protein-protein interactions (PPIs) between viruses and human proteins is crucial for uncovering infection mechanisms and identifying potential therapeutic targets. The ability to generalize PPI predictive models across understudied viruses presents a significant challenge. In this work, we use arenavirus-human PPIs to illustrate the difficulties associated with model generalization, which are compou...

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Literature Corpus work: 04f94828-6fc4-5b9a-a05c-52d063f57e9e
DOI: 10.1101/2025.04.16.649136

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