Article

Beyond the nucleus: Plastic chemicals activate G protein-coupled receptors

2023-10-06

Abstract excerpt

<h4>Abstract Figure</h4> G protein-coupled receptors (GPCRs) are central mediators of cell signaling and physiological function. Despite their biological significance, GPCRs have not been widely studied in the field of toxicology. Herein, we investigated these receptors are novel targets of plastic chemicals using a high-throughput drug screening assay with 126 human non-olfactory GPCRs. In a first-pass screen, w...

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Literature Corpus work: 04d41fb8-0245-5141-af35-f416bffd87d3
DOI: 10.1101/2023.10.04.560665

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