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Alpelisib Exhibits a Synergistic Effect with Pyrotinib and Reverses Acquired Pyrotinib Resistance in HER2+ Breast Cancer

2022-01-05

Abstract excerpt

<h4>Background: </h4> Human epidermal growth factor receptor 2 (HER2) plays a vital role in breast cancer progression in patients who overexpress HER2, thus promoting the rapid progress of targeted drugs development and therapy strategies advancement targeting this gene. Pyrotinib, approved in clinical by the Chinese State Drug Administration, is a novel pan-ErbB kinase inhibitor and exhibits better efficacy than...

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Literature Corpus work
045f9a7f-1d27-5ce3-bbc9-e7ab4b6e89ba
DOI
10.21203/rs.3.rs-1221004/v1
Open publication

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Alpelisib Exhibits a Synergistic Effect with Pyrotinib and Reverses Acquired Pyrotinib Resistance in HER2+ Breast CancerDOI 10.21203/rs.3.rs-1221004/v1
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