Article

Somatic drift and rapid loss of heterozygosity suggest small effective population size of stem cells and high somatic mutation rate in asexual planaria

2019-06-10

Abstract excerpt

Planarian flatworms have emerged as highly promising models of body regeneration due to the many stem cells scattered through their bodies. Currently, there is no consensus as to the number of stem cells active in each cycle of regeneration or the equality of their relative contributions. We approached this problem with a population genetic model of somatic genetic drift. We modeled the fissiparous life cycle of a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 044b7211-349f-53e3-b518-e04190973b10
DOI: 10.1101/665166

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Somatic drift and rapid loss of heterozygosity suggest small effective population size of stem cells and high somatic mutation rate in asexual planariaDOI 10.1101/665166Read

Mutational profile of the regenerative process and <i>de novo</i> genome assembly of the planarian <i>Schmidtea polychroa</i>Semantic proximity Read

Mutational profile of the regenerative process and de novo genome assembly of the planarian Schmidtea polychroa.Semantic proximity Read

What sets the mutation rate of a cell type in an animal species?Semantic proximity Read

Precise age estimation in clonal species using a somatic genetic clockSemantic proximity Read

A somatic genetic clock for clonal species.Semantic proximity Read

Somatic genetic drift and multi-level selection in modular speciesSemantic proximity Read

Gene conversion limits the cost of asexuality in somatically immortal wormsSemantic proximity Read

Do clones degenerate over time? Explaining the genetic variability of asexuals through population genetic models.Semantic proximity Read

Somatic mutations in organisms with complex life histories.Semantic proximity Read

Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual wormsSemantic proximity Read

De Novo Mutation Rates in Sticklebacks.Semantic proximity Read