Back to search

Article

Extended single-dose toxicity study of [211At]meta-astatobenzylguanidine in normal mice in preparation for the first-in-human clinical trial of targeted alpha therapy for pheochromocytoma and paraganglioma

2025-04-24

Abstract excerpt

<title>Abstract</title> <p>Objective Targeted alpha-particle therapy (TAT) is promising with a greater therapeutic effect than conventional beta radionuclide therapy. To develop human clinical trials of [<sup>211</sup>At]<italic>meta</italic>-astatobenzylguanidine ([<sup>211</sup>At]MABG), we have conducted an extended single-dose toxicity study of [<sup>211</sup>At]MABG in normal mice in consultation with the P...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
03c22a4c-ae90-577e-b52d-04e9b97253dc
DOI
10.21203/rs.3.rs-6059261/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 10 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Extended single-dose toxicity study of [211At]meta-astatobenzylguanidine in normal mice in preparation for the first-in-human clinical trial of targeted alpha therapy for pheochromocytoma and paragangliomaDOI 10.21203/rs.3.rs-6059261/v1
National Cancer Institute Support for Targeted Alpha-Emitter TherapySemantic proximity
Transcriptional response in normal mouse tissues after i.v. 211At administration - response related to absorbed dose, dose rate, and timeSemantic proximity
Revisiting the Radiobiology of Targeted Alpha TherapySemantic proximity
Safety Evaluation of 177 Lu-TEFAPI-06 with Long-Term Blood Circulation in RodentsSemantic proximity
Dose Escalation Biodistribution, Positron Emission Tomography/Computed Tomography Imaging and Dosimetry of a Highly Specific Radionuclide-labeled Non-blocking NanobodySemantic proximity
The Radiolabeling of [161Tb]-PSMA-617 by a Novel Radiolabeling Method and Preclinical Evaluation by In Vitro/In Vivo Methods.Semantic proximity
Dosimetry-Driven Alpha Emitter Selection for Radioligand Therapy: Is daughter translocation a significant safety concern?Semantic proximity
Estimating the tolerance of Brachial Plexus to hypofractionated Stereotactic Body Radiotherapy – A modelling-based approach from clinical experience.Semantic proximity
A Phase I Trial of First-in-Human Alpha-Emitter Astatine-211-Labeled Anti-CD45 Antibody (211At-BC8-B10) in Combination with Fludarabine and TBI As Conditioning for Allogeneic Hematopoietic Cell Transplantation (HCT) for Patients with Refractory/Relapsed Leukemia or High-Risk Myelodysplastic Syndrome (MDS): Preliminary Results of Dose EscalationSemantic proximity
Fully Automated Production of [68Ga]FAPI-46 with Gallium-68 from Cyclotron Using Liquid TargetsSemantic proximity
Select a neighboring publication to make it the new centre.