Article

Metabolic flux analysis in hiPSC-CMs reveals insights into cardiac dysfunction in propionic acidemia

2025-01-28

Abstract excerpt

<title>Abstract</title> <p>Propionic acidemia is an inborn error of metabolism caused by mutations in either the <italic>PCCA</italic> or <italic>PCCB</italic> genes. Patients with propionic acidemia experience a range of complications, including life-threatening cardiac dysfunctions. However, the pathological mechanisms underlying propionic acidemia-associated cardiac diseases remain largely unknown. To gain ins...

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Literature Corpus work: 0128712e-d20f-59d7-a054-b9ca94523b7a
DOI: 10.21203/rs.3.rs-5874705/v1

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