Article
High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands.
American journal of human genetics - 1 Feb 1999
Rizzu P, Van Swieten J C, Joosse M, Hasegawa M, Stevens M, Tibben A, Niermeijer M F, Hillebrand M, Ravid R, Oostra B A, Goedert M, van Duijn C M, Heutink P
Abstract excerpt
Mutations in microtubule-associated protein tau recently have been identified in familial cases of frontotemporal dementia (FTD). We report the frequency of tau mutations in a large population-based study of FTD carried out in the Netherlands from January 1994 to June 1998. Thirty-seven patients...
Topics
- Dementia
- Female
- Frontal Lobe
- Gene Deletion
- Humans
- Male
- Middle Aged
- Mutation
- Mutation, Missense
- Netherlands
- Point Mutation
- Prevalence
- Temporal Lobe
- tau Proteins