Article
High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands.
American journal of human genetics - 1 Feb 1999
Rizzu P, Van Swieten J C, Joosse M, Hasegawa M, Stevens M, Tibben A, Niermeijer M F, Hillebrand M, Ravid R, Oostra B A, Goedert M, van Duijn C M, Heutink P
Abstract excerpt
Mutations in microtubule-associated protein tau recently have been identified in familial cases of frontotemporal dementia (FTD). We report the frequency of tau mutations in a large population-based study of FTD carried out in the Netherlands from January 1994 to June 1998. Thirty-seven patients had >/=1 first-degree relative with dementia. A mutation in the tau gene was found in 17.8% of the group of patients...
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