Increased hydroxyl radical production and apoptosis in PC12 neuron cells expressing the gain-of-function mutant G93A SOD1 gene.

Abstract excerpt

Mutations of the SOD1 gene (formerly known as Cu,Zn-SOD) are frequently associated with the familial form of amyotrophic lateral sclerosis (ALS). The G93A mutation of SOD1 with substitution of Gly to Ala at residue 93 results in gain of a peroxidative function. Here we report that transfection of...

Topics

• Animals
• Apoptosis
• Binding Sites
• Blotting, Northern
• Blotting, Western
• Gene Expression
• Hydroxyl Radical
• Mutation
• Neurons
• PC12 Cells
• Protein Conformation
• Rats
• Superoxide Dismutase