Article
Independent and joint effects of family history and lifestyle on colorectal cancer risk: implications for prevention.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 1999
Le Marchand L, Wilkens L R, Hankin J H, Kolonel L N, Lyu L C
Abstract excerpt
It has been suggested that, for a substantial proportion of "sporadic" colorectal cancers (CRCs), inheritance determines individual susceptibility and that lifestyle determines which susceptible individuals express cancer. Because the genetic basis of this inherited susceptibility remains undefined, we used family history of the disease as a proxy for a genetic predisposition to examine its interactions with a...
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