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Article

Na+-driven flagellar motor resistant to phenamil, an amiloride analog, caused by mutations in putative channel components.

Journal of molecular biology - 29 Jan 1999

Kojima S, Asai Y, Atsumi T, Kawagishi I, Homma M

Abstract excerpt

The rotation of the Na+-driven flagellar motor is specifically and strongly inhibited by phenamil, an amiloride analog. Here, we provide the first evidence that phenamil interacts directly with the Na+-channel components (PomA and PomB) of the motor. The alterations in Mpar (motility resistant to phenamil) strains were mapped to the pomA and/or pomB genes. We cloned and sequenced pomA and pomB from two Mpar...

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Identifiers

PMID: 9917395
DOI: 10.1006/jmbi.1998.2377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Na+-driven flagellar motor resistant to phenamil, an amiloride analog, caused by mutations in putative channel components.PMID 9917395Read ↗

Vibrio alginolyticus mutants resistant to phenamil, a specific inhibitor of the sodium-driven flagellar motor.Semantic proximity Read ↗

Mutations conferring resistance to phenamil and amiloride, inhibitors of sodium-driven motility of Vibrio parahaemolyticus.Semantic proximity Read ↗

Multimeric structure of PomA, a component of the Na+-driven polar flagellar motor of vibrio alginolyticus.Semantic proximity Read ↗

A slow-motility phenotype caused by substitutions at residue Asp31 in the PomA channel component of a sodium-driven flagellar motor.Semantic proximity Read ↗

Interaction of PomB with the third transmembrane segment of PomA in the Na+-driven polar flagellum of Vibrio alginolyticus.Semantic proximity Read ↗

Sodium-dependent dynamic assembly of membrane complexes in sodium-driven flagellar motors.Semantic proximity Read ↗

The systematic substitutions around the conserved charged residues of the cytoplasmic loop of Na+-driven flagellar motor component PomA.Semantic proximity Read ↗

The function of the Na+-driven flagellum of Vibrio cholerae is determined by osmolality and pH.Semantic proximity Read ↗

The evolution of a Na+-sensitive Vibrio cholerae mutant unmasks the moonlighting aminopeptidase PepA as a regulator of nhaB Na+/H+ antiporter gene expression.Semantic proximity Read ↗

Cloning and characterization of motX, a Vibrio alginolyticus sodium-driven flagellar motor gene.Semantic proximity Read ↗

Mutational analysis and overproduction effects of MotX, an essential component for motor function of Na+-driven polar flagella of Vibrio.Semantic proximity Read ↗

Mutations in the MotA protein of Escherichia coli reveal domains critical for proton conduction.Semantic proximity Read ↗

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