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Article

The human <i>LARGE</i> gene from 22q12.3-q13.1 is a new, distinct member of the glycosyltransferase gene family

19 Jan 1999

Abstract excerpt

Meningioma, a tumor of the meninges covering the central nervous system, shows frequent loss of material from human chromosome 22. Homozygous and heterozygous deletions in meningiomas defined a candidate region of >1 Mbp in 22q12.3-q13.1 and directed us to gene cloning in this segment. We characterized a new member of the N-acetylglucosaminyltransferase gene family, the LARGE gene. It occupies >664 kilobases and...

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PMID: 9892679
DOI: 10.1073/pnas.96.2.598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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