A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor.

doi:10.1093/hmg/8.1.81

Article

A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor.

Human molecular genetics - 1 Jan 1999

Farrer M, Gwinn-Hardy K, Muenter M, DeVrieze F W, Crook R, Perez-Tur J, Lincoln S, Maraganore D, Adler C, Newman S, MacElwee K, McCarthy P, Miller C, Waters C, Hardy J

Abstract excerpt

We investigated a large family with levodopa-responsive, Lewy body parkinsonism in which the disease segregates as an apparent autosomal dominant trait. After performing a genome screen, we identified a chromosome 4p haplotype that segregates with the disease. However, this haplotype also occurs in individuals in the pedigree who do not have clinical Lewy body parkinsonism but rather suffer from postural tremor,...

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