Test of candidate gene--quantitative trait locus association applied to fatness in mice.

doi:10.1046/j.1365-2540.1998.00450.x

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Article

Test of candidate gene--quantitative trait locus association applied to fatness in mice.

Heredity - 1 Dec 1998

Keightley P D, Morris K H, Ishikawa A, Falconer V M, Oliver F

Abstract excerpt

We test for the contribution of five strong candidate genes for obesity to quantitative variation for fatness in mice. The candidate loci are known through their major mutant phenotypes. We propose a randomization test for overall contribution of candidate genes, based on the empirical distributi...

Topics

Adipose Tissue
Animals
Chromosome Mapping
Crosses, Genetic
Female
Genetic Linkage
Homozygote
Hybridization, Genetic
Likelihood Functions
Lod Score
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mutation
Obesity
Quantitative Trait, Heritable

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