[Physiopathology of diabetic neuropathies. Functional exploration of peripheral involvement].

Abstract excerpt

Neuropathy is a common complication of Type 1 and Type 2 diabetes. In the peripheral nerve, persistent hyperglycaemia leads to metabolic and vascular disorders responsible for nerve fibre abnormalities. Genetic predisposition has been mentioned more recently. Among metabolic factors, an increase of the polyol pathway, a linoleic acid metabolism abnormality, a decrease of carnitine level, an increase of protein...

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