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Article

Regulated Delivery of Therapeutic Proteins After in Vivo Somatic Cell Gene Transfer

1 Jan 1999

Abstract excerpt

Stable delivery of a therapeutic protein under pharmacologic control was achieved through in vivo somatic gene transfer. This system was based on the expression of two chimeric, human-derived proteins that were reconstituted by rapamycin into a transcription factor complex. A mixture of two adeno-associated virus vectors, one expressing the transcription factor chimeras and one containing erythropoietin (Epo)...

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PMID: 9872748
DOI: 10.1126/science.283.5398.88

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