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Tissue-Engineered Skeletal Muscle Organoids for Reversible Gene Therapy

10 Nov 1996

Abstract excerpt

Genetically modified murine skeletal myoblasts were tissue engineered in vitro into organ-like structures (organoids) containing only postmitotic myofibers secreting pharmacological levels of recombinant human growth hormone (rhGH). Subcutaneous organoid implantation under tension led to the rapid and stable appearance of physiological sera levels of rhGH for up to 12 weeks, whereas surgical removal led to its...

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PMID: 8934233
DOI: 10.1089/hum.1996.7.17-2195

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