Article
The aberrant expression of Lewis a antigen in intestinal metaplastic cells of gastric mucosa is caused by augmentation of Lewis enzyme expression.
Glycoconjugate journal - 1 Aug 1998
Ikehara Y, Nishihara S, Kudo T, Hiraga T, Morozumi K, Hattori T, Narimatsu H
Abstract excerpt
Immunohistochemical staining showed an aberrant expression of Le(a) antigen in the intestinal metaplastic glands of the gastric mucosa of secretors, as reported by others. In this study, we have demonstrated for the first time that the Lewis enzyme is well colocalized with Le(a) antigen, indicati...
Topics
- Adult
- Aged
- Aged, 80 and over
- Female
- Fucosyltransferases
- Gangliosides
- Gastric Mucosa
- Gene Expression
- Genotype
- Humans
- Immunohistochemistry
- Lewis Blood Group Antigens
- Male
- Metaplasia
- Middle Aged
- Polymerase Chain Reaction
- Up-Regulation