Article
Mutations in the hepatocyte nuclear factor-1alpha gene in Caucasian families originally classified as having Type I diabetes.
Diabetologia - 1 Dec 1998
Møller A M, Dalgaard L T, Pociot F, Nerup J, Hansen T, Pedersen O
Abstract excerpt
Mutations in the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene are the cause of maturity-onset diabetes of the young type 3 (MODY3), which is characterised by a severe impairment of insulin secretion and an early onset of the disease. Also at onset of diabetes some MODY patients show similar...
Topics
- Adolescent
- Adult
- Child
- Child, Preschool
- DNA-Binding Proteins
- Diabetes Mellitus, Type 1
- Diabetes Mellitus, Type 2
- Diagnosis, Differential
- Exons
- Female
- Frameshift Mutation
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Humans
- Male
- Mutation
- Mutation, Missense