Fluorescence in situ hybridization analysis of the replication properties of the myotonic dystrophy protein kinase (DMPK) gene region.

doi:10.1159/000015111

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Article

Fluorescence in situ hybridization analysis of the replication properties of the myotonic dystrophy protein kinase (DMPK) gene region.

Cytogenetics and cell genetics - 1 Jan 1998

Rajcan-Separovic E, Barcelo J M, Korneluk R G

Abstract excerpt

Myotonic dystrophy (DM) is caused by an expansion of a CTG repeat sequence in the 3' noncoding region of a protein kinase gene (DMPK) at 19q13.3. We used in situ hybridization to analyse the replication timing of the genomic region containing DMPK in fibroblasts and myoblasts from controls and my...

Topics

Alleles
Cells, Cultured
Cosmids
DNA Mutational Analysis
DNA Replication
Fibroblasts
Humans
In Situ Hybridization, Fluorescence
Muscle Fibers, Skeletal
Myotonic Dystrophy
Myotonin-Protein Kinase
Protein Serine-Threonine Kinases
Skin
Trinucleotide Repeats

Source

Open in PubMed

Identifiers

PMID: 9858828
DOI: 10.1159/000015111

Genes

DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9858828-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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