Effect of the myotonic dystrophy (DM) mutation on mRNA levels of the DM gene.

doi:10.1038/ng0793-233

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Article

Effect of the myotonic dystrophy (DM) mutation on mRNA levels of the DM gene.

Nature genetics - 1 Jul 1993

Sabouri L A, Mahadevan M S, Narang M, Lee D S, Surh L C, Korneluk R G

Abstract excerpt

Myotonic dystrophy (DM) results from the amplification of an unstable CTG repeat in the 3' untranslated region of a transcript encoding a putative serine/threonine kinase. We have analysed the amplification of the repeat and the steady state levels of the DM kinase (DMK) mRNA in tissues and cell...

Topics

Alleles
Base Sequence
DNA
Gene Amplification
Gene Expression
Genes, Dominant
Humans
Infant, Newborn
Molecular Sequence Data
Mutation
Myotonic Dystrophy
Oligodeoxyribonucleotides
Protein Serine-Threonine Kinases
RNA, Messenger
Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 8358430
DOI: 10.1038/ng0793-233

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8358430-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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