Article
The haemochromatosis mutations do not modify the clinical picture of thalassaemia major in patients regularly transfused and chelated.
British journal of haematology - 1 Dec 1998
Borgna-Pignatti C, Solinas A, Bombieri C, Micciolo R, Gamberini M R, De Stefano P, De Menis E, Pignatti P F
Abstract excerpt
Iron overload is the main cause of morbidity and mortality in patients with thalassaemia major. In order to establish if the presence of the mutations recently described in the haemochromatosis gene affects the severity of iron overload in thalassaemia patients, we compared the prevalence of muta...
Topics
- Adolescent
- Adult
- Blood Transfusion
- Chelation Therapy
- Female
- Hemochromatosis
- Heterozygote
- Homozygote
- Humans
- Male
- Mutation
- beta-Thalassemia