Article
Production of trypsins by human gastric cancer cells correlates with their malignant phenotype.
European journal of cancer (Oxford, England : 1990) - 1 Jun 1998
Kato Y, Nagashima Y, Koshikawa N, Miyagi Y, Yasumitsu H, Miyazaki K
Abstract excerpt
Proteolytic degradation of extracellular matrix is a critical step in tumour invasion and metastasis. To examine the role of trypsin in tumour dissemination, we cloned two variants (S4 and R3 cells) from STKM-1, a trypsinogen 1-producing diffuse gastric cancer cell line. Western blot analysis wit...
Topics
- Animals
- Blotting, Western
- Humans
- Mice
- Mice, Nude
- Neoplasm Proteins
- Phenotype
- RNA, Messenger
- Reverse Transcriptase Polymerase Chain Reaction
- Stomach Neoplasms
- Trypsin
- Trypsinogen
- Tumor Cells, Cultured