Article
Decreased frequency of rearrangement due to the synergistic effect of nucleotide changes in the heptamer and nonamer of the recombination signal sequence of the V kappa gene A2b, which is associated with increased susceptibility of Navajos to Haemophilus influenzae type b disease.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1998
Nadel B, Tang A, Lugo G, Love V, Escuro G, Feeney A J
Abstract excerpt
Navajos and genetically related populations have a 10-fold increased incidence of Haemophilus influenzae type b (Hib) disease compared with control populations. The Vkappa gene A2 is used to encode the majority of anti-Hib Abs, and these are the highest affinity anti-Hib Abs. Navajos carry a diff...
Topics
- Alleles
- Base Sequence
- Cell Line, Transformed
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes, Immunoglobulin
- Genetic Predisposition to Disease
- Haemophilus influenzae type b
- Humans
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Indians, North American
- Meningitis, Haemophilus