Article
Maternally-inherited diabetes and deafness: report of two affected German families with the A3243G mitochondrial DNA mutation.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Jan 1998
Thorns C, Widjaja A, Boeck N, Skamira C, Zühlke H
Abstract excerpt
In two German families four patients containing the A3243G mutant in the mitochondrial DNA suffered from maternally-inherited diabetes and deafness (MIDD). DNA was isolated from oral mucosa cells. Using the polymerase chain reaction with not yet published primers, we obtained after digestion with...
Topics
- Adolescent
- Adult
- Child, Preschool
- DNA, Mitochondrial
- Deafness
- Diabetes Complications
- Diabetes Mellitus
- Female
- Germany
- Humans
- Male
- Middle Aged
- Mouth Mucosa
- Mutation
- Pedigree