Article
Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Dec 1998
Bursztajn S, DeSouza R, McPhie D L, Berman S A, Shioi J, Robakis N K, Neve R L
Abstract excerpt
Programmed cell death, or apoptosis, has been implicated in Alzheimer's disease (AD). DNA damage was assessed in primary cortical neurons infected with herpes simplex virus (HSV) vectors expressing the familial Alzheimer's disease (FAD) gene presenilin-1 (PS-1) or an FAD mutant of this gene, A246...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Apoptosis
- Bisbenzimidazole
- Cell Survival
- Cerebral Cortex
- DNA Fragmentation
- Fluorescent Dyes
- Gene Expression
- Humans
- In Situ Nick-End Labeling
- Membrane Proteins
- Mutation
- Nerve Degeneration